What are the best heavy grenade launchers in Destiny 2? We’re answering that and more with our ranked list below!

Heavy grenade launchers in Destiny 2 boast extremely high DPS in any combat situation, especially against lategame bosses. Be they single-round kinetics or magazine-loading power weapons, you’ll always get a bang for your buck.. if you grind for the right ones.

Best Heavy Grenade Launchers in Destiny 2

5. Cataphract

Destiny 2 best heavy grenade launchers Cataphract
Screenshot by Paul Gono/ONE Esports

Despite bursting into the scene in 2023, the Cataphract GL3 stays relevant due to having top tier perks. 

While it’s not as flashy as the other heavy grenade launchers on our list, its stability, DPS, and velocity puts it toe-to-toe with popular god rolls, making it  viable against any PVE boss.

4. Wicked Sister

Destiny 2 best heavy grenade launchers -- Wicked Sister
Screenshot by Paul Gono/ONE Esports

Wicked Sister is the latest grenade launcher added to the Vanguard playlist, and is a legendary with considerable stats. Just scoring Envious Arsenal with something like Bait & Switch makes it so that you never have to reload. That said, its lackluster origin trait puts it behind some of the best heavy grenade launchers in the game.

3. Bitter/Sweet

Destiny 2 best heavy grenade launchers Bittersweet
Screenshot by Paul Gono/ONE Esports

Bitter/Sweet’s god roll performs spectacularly in the current Destiny 2 episode. And despite being a seasonal drop, obscenely high damage numbers make B/S worth picking up. 

Run this heavy GL with Bait & Switch’s 30% damage buff, Envious Arsenal’s instant refills, the origin trait that overfills the mag, and an Arc surge match for 25% more DPS. 



2. Edge Transit

Destiny 2 best heavy grenade launchers Edge Transit
Screenshot by Paul Gono/ONE Esports

What was once a huge meme in the Destiny 2 community has become one of the best heavy grenade launchers after the 2024 buffs. With the proper perks – and a well-executed rotation – you can crush dungeon bosses before their second phase. On top of that, grinding Onslaught feels absolutely worth it due to the other fantastic drops you can get!

1. VS Chill Inhibitor

Best heavy grenade launchers in Destiny 2 -- VS Chill Inhibitor
Screenshot by Paul Gono/ONE Esports

At the top of our list is the VS Chill Inhibitor – a DPS player’s wet dream whose 150rpm gets even crazier once you pair it with Cascade Point. Stasis might be a niche element, but this HGL can dish out the hurt relentlessly, trading in blast radius and zoom for speed and accuracy to take down PVE dungeon bosses in less than a minute.

READ MORE: D2Red Tape god roll — dominate PvP and PvE